The PROCAMIO Study(1)
This was a randomised (non-blinded) open labelled study. 62 haemodynamically stable patients with sustained, monomorphic, Ventricular Tachycardia(VT), were assigned to receive either:
(i) intravenous procainamide (single dose 10 mg/kg over 20 min) or
(ii) intravenous amiodarone (single dose 5 mg/kg over 20 min).
The study period was 40 min from infusion initiation (20 min for drug administration and 20 min following administration). There was an observation period of 24 h after the end of the study period.
The primary endpoint of the study was the incidence of major cardiac adverse events.
Secondary end-points were:
(i) the efficacy of both drugs in relation to the acute termination of the tachycardia episode and
(ii) the incidence of total adverse events during the observation period.
Overall the termination of VT occurred in 33 patients (53%). 67% of patients treated with procainamide reverted, compared to 38% of those treated with amiodarone.
As an adverse event, hypotension occurred in 8 patients on procainamide and 14 patients on amiodarone.
Comments
1 It’s interesting that the primary endpoint was not reversion. However it makes sense to see if a drug is tolerated. In one previous study(2) the rate of hypotension was higher with Procainamide.
2 Original anticipated numbers not reached in the study, so we need to be careful of the conclusions.
3 The dose of Procainamide used, was taken from a previous study that comparing procainamide with lignocaine(2). 10mg/kg was used. Usual dosage is 17 mg/kg given at a max rate of 50 mg/min, or 100 mg over 2 minutes every 5 minutes until conversion. A higher dosage may be associated with more symptoms. However even at this lower dosage used in this study, the efficacy was there.
Previous Studies
A previous retrospective study comparing Amiodarone and Procainamide(3) looked at arrhythmia termination within 20 minutes of infusion. There were 90 patients in this study. The rates of VT termination were 25% (13/53) and 30% (9/30) for amiodarone and procainamide, respectively.
Ultimately, 35/66 amiodarone patients (53%, 95% CI=40 to 65%) and 13/31 procainamide patients (42%, 95% CI=25 to 61%) required electrical therapy for VT termination. Hypotension led to cessation of infusion or immediate direct current cardioversion (DCCV) in 4/66 amiodarone and 6/31 of procainamide, respectively.
In some countries it’s hard to get Procainamide. It certainly has been in Australian ED’s. However it is available and is used by electrophysiologists. We certainly now have this in my ED. Why do I like it? Not only can I use it for VT, but I can use it for AF with WPW, due to its actions on the accessory pathways.
References
1 Ortiz1, M et al. Randomized comparison of intravenous procainamide vs. intravenous amiodarone for the acute treatment of tolerated wide QRS tachycardia: the PROCAMIO study. European Heart Journal June 28, 2016
2 Gorgels AP, et al.. Comparison of procainamide and lidocaine in terminating sustained monomorphic ventricular tachycardia. Am J Cardiol 1996;78:43–46.
3 Marill KA et al Amiodarone or procainamide for the termination of sustained stable ventricular tachycardia: an historical multicenter comparison. Acad Emerg Med 2010;17:297 – 306.
This information is priceless. When can I find out
more?
I visit daily some sites and websites to read articles or reviews,
but this weblog offers feature based articles.
Feel free to surf to my webpage great sex tips (tanglewood.sh)
I really like what you guys are usually up too. This type
of clever work and reporting! Keep up the good works
guys I’ve added you guys to blogroll.
my web page :: making sex better
I think this site has got some rattling good information for everyone :
D.
Visit my web blog … paleo diet tips
Excellent post. I’m experiencing a few of these
issues as well..
my web blog; pubic hair removal
I pay a visit daily some blogs and sites to read articles, however this weblog provides
feature based articles.
Here is my webpage :: eating healthy (forum.m2clasic.ro)
I besides think thus, perfectly written post!
my web site sex technique
Your method of telling the whole thing in this piece of
writing is really fastidious, all can without difficulty know it, Thanks a lot.
My web page – http://www.fotosombra.com.br
Yay google is my queen assisted me to find this great internet site!
Review my blog post :: carb diet (forum.m2clasic.ro)
Thanks for the sensible critique. Me and my neighbor were
just preparing to do a little research on this. We got a grab a book
from our local library but I think I learned more from this post.
I’m very glad to see such magnificent info being shared freely out there.
Here is my site :: hemp seed oil uses (http://www.a913.vip/forum.php?mod=viewthread&tid=2131469)
I want to to thank you for this good read!! I absolutely loved
every bit of it. I have you bookmarked to look at new things you post…
Check out my web site :: drug abuse treatment [http://www.aniene.net/modules.php?name=Your_Account&op=userinfo&username=OlgaBurd4]
Hi there, I check your blog daily. Your humoristic style
is awesome, keep doing what you’re doing!
Take a look at my website skilled drug
Amazing! This blog looks just like my old one!
It’s on a completely different subject but it has pretty much the same page layout and design. Wonderful choice of colors!
Stop by my site – cannabis dispensaries-san
Utterly written content, regards for selective information.
Stop by my web-site; enjoy sex better
Nice post. I was checking constantly this blog and
I am inspired! Very useful info particularly the final phase 🙂 I deal
with such info much. I was seeking this certain info for a very lengthy time.
Thank you and good luck.
Feel free to surf to my website; cannabis doctor
Its not my first time to pay a visit this web site, i am visiting this web site dailly and get pleasant facts from here every day.
My page … hemp seed oil uses
I visited various web sites however the audio feature for audio
songs current at this web page is truly wonderful.
Also visit my web blog … growing cannabis
Why viewers still use to read news papers when in this technological world everything
is presented on net?
Also visit my homepage: purchase hemp
Hello.This article was really motivating, especially because I was investigating for thoughts on this topic
last Tuesday.
Feel free to visit my blog: lose belly fat
I have been exploring for a little bit for any high quality articles or weblog
posts in this kind of area . Exploring in Yahoo I at
last stumbled upon this site. Studying this information So
i’m happy to exhibit that I have an incredibly good uncanny feeling I came upon just what I needed.
I so much indisputably will make sure to do not omit this site and give it a glance regularly.
My web site; seeds require
Actually no matter if someone doesn’t understand afterward its up to other viewers that they will assist, so here it occurs.
Here is my blog post – seeds prior
You actually make it seem so easy with your presentation but I find this
topic to be actually something that I think I would never understand.
It seems too complicated and extremely broad for me.
I am looking forward for your next post, I will try
to get the hang of it!
Here is my web page; http://www.hltkd.tw
Keep on working, great job!
My webpage – growing mini-course
Hi there! This post couldn?t be written any better! Reading through this
article reminds me of my previous roommate! He continually
kept preaching about this. I will send this post to him.
Fairly certain he’s going to have a great read. Thank you for sharing!
my web page :: low carbohydrate dieting
I have recently started a website, the info you offer on this
web site has helped me tremendously. Thanks for all of your time &
work.
Also visit my webpage – rid belly fat
I truly value your piece of work, Great post.
Also visit my webpage … anti aging skin care
Pretty! This was an extremely wonderful post.
Thanks for supplying these details.
Take a look at my blog – natural libido pills
I am glad to be one of several visitants on this outstanding website (:,
thanks for putting up.
My blog post; healthy lifestyle
Thank you for the blog post. Velupe and I have
already been saving for our new e-book on this theme
and your article has made people like us to save our own money.
Your thoughts really responded to all our problems. In fact,
greater than what we had thought of before we came upon your
superb blog. My partner and i no longer nurture doubts including a troubled mind because you have attended to each of our
needs right here. Thanks
My website :: dry itchy skin
Thanks for any other magnificent post. Where
else may anyone get that kind of info in such a perfect means of writing?
I’ve a presentation subsequent week, and I am on the look for such info.
Feel free to visit my page :: fad diets bullshit
Howdy! Do you know if they make any plugins to protect against hackers?
I’m kinda paranoid about losing everything I’ve worked
hard on. Any tips?
Review my web-site: bbs.yunweishidai.com
Excellent items from you, man. I’ve have in mind your
stuff prior to and you are just extremely great. I actually
like what you have acquired right here, really like what you are saying and the
way in which by which you are saying it. You are making it entertaining and you still take care of to stay it wise.
I can’t wait to read much more from you.
That is really a terrific web site.
Also visit my site hemp farming
I get pleasure from, cause I discovered just what I was taking a look for.
You have ended my four day long hunt! God Bless you man. Have
a nice day. Bye
Look at my webpage; hemp seed oil uses
I conceive this website contains some really
wonderful info for everyone :D.
Feel free to visit my web-site zwiazek-zawodowy-opiekunek.pl
I believe what you published was very logical. However, what about this?
what if you were to write a awesome headline?
I ain’t suggesting your content is not good., but suppose you
added something that makes people want more?
I mean Amiodarone vs Procainamide for Ventricular Tachycardia – Resus is kinda boring.
You should look at Yahoo’s front page and note how they write post headlines to grab people interested.
You might add a video or a picture or two to get readers excited about everything’ve written. In my opinion, it might bring your posts a little bit more interesting.
Feel free to visit my blog; Veronique
Whoah this weblog is wonderful i really
like reading your articles. Keep up the great work!
You understand, a lot of individuals are looking round for this information, you can help them greatly.
Have a look at my webpage how to remove acne scars
Pretty section of content. I just stumbled upon your blog and in accession capital
to assert that I acquire actually enjoyed account your blog
posts. Anyway I’ll be subscribing to your augment and even I
achievement you access consistently quickly.
Hi there, I think your blog could be having browser
compatibility issues. Whenever I take a look at your website in Safari, it looks fine but
when opening in I.E., it’s got some overlapping issues.
I simply wanted to give you a quick heads up!
Besides that, excellent blog!
Hello! I just wanted to ask if you ever have any trouble with hackers?
My last blog (wordpress) was hacked and I ended up losing months of
hard work due to no backup. Do you have any methods to protect against hackers?
my website :: sexual position
Good information. Lucky me I came across your website by accident (stumbleupon).
I have saved it for later!
Also visit my web page – email marketing
Awesome! Its genuinely awesome paragraph, I have got much clear idea concerning from this piece of writing.
You can definitely see your enthusiasm in the article you write.
The world hopes for more passionate writers like you who are not
afraid to say how they believe. At all times follow your heart.
Look at my homepage … diets that work
Pretty! This was a really wonderful post. Many thanks for
providing this info.
I?m not that much of a online reader to be honest but your
blogs really nice, keep it up! I’ll go ahead and bookmark your website to come back later.
All the best
Have a look at my web-site; teen weightloss
I reckon something really interesting about your web blog so I
saved talk to each other about sex (hypnotronstudios.com) fav.
It’s very easy to find out any matter on web as compared to textbooks, as I found this article at this
site.
Look at my web blog: quick weight loss pills – ibbs.uu.cc,
My coder is trying to persuade me to move to .net from PHP.
I have always disliked the idea because of the expenses. But he’s tryiong
none the less. I’ve been using WordPress on various websites for about a year
and am anxious about switching to another platform. I have heard great
things about blogengine.net. Is there a way I can import all my wordpress content into it?
Any kind of help would be greatly appreciated!
Asking questions are truly nice thing if you
are not understanding something totally, however this paragraph offers fastidious understanding even.
Good ? I should definitely pronounce, impressed with your web site.
I had no trouble navigating through all tabs as well as related information ended up being truly
simple to do to access. I recently found what I hoped for
before you know it at all. Reasonably unusual. Is likely to
appreciate it for those who add forums or anything, site theme
. a tones way for your customer to communicate. Nice task.
My website: drug abuse treatment
If you desire to grow your know-how simply keep visiting
this site and be updated with the latest news update posted here.
It’s not my first time to visit this web page, i am browsing this web page dailly and take good
data from here daily.
My web-site: boost libido in men
Your style is so unique in comparison to other people I’ve read stuff from.
I appreciate you for posting when you have the opportunity,
Guess I’ll just bookmark this blog.
my web blog: high fat (forums.draininggroundwaterforum.org)
What’s up, I want to subscribe for this web site to take latest updates,
so where can i do it please help out.
If you are going for best contents like I do, simply visit this web site all the time as it gives feature contents, thanks
It’s an awesome paragraph in favor of all the online visitors; they
will take advantage from it I am sure.
Hola! I’ve been reading your weblog for a while now and finally got the courage to go ahead and give you a
shout out from Huffman Texas! Just wanted to tell you keep up the good work!
This is very fascinating, You are a very skilled blogger.
I’ve joined your feed and stay up for in the hunt
for more of your wonderful post. Additionally, I’ve shared your web site in my social networks
Hi there! I’m at work surfing around your blog from my new
apple iphone! Just wanted to say I love reading through your blog and
look forward to all your posts! Keep up the great work!
It’s appropriate time to make some plans for the future and it’s time to be happy.
I’ve read this post and if I could I desire to suggest you few interesting things or tips.
Maybe you could write next articles referring to this article.
I wish to read even more things about it!
If some one needs to be updated with latest technologies
then he must be pay a quick visit this web site
and be up to date everyday.
This is very interesting, You’re a very skilled blogger. I have joined your feed and look forward to seeking more
of your wonderful post. Also, I have shared your site in my social networks!
Excellent post. I was checking constantly this blog and I am impressed!
Extremely helpful info specifically the last part 🙂 I care for such information a lot.
I was seeking this particular information for
a very long time. Thank you and best of luck.
Great blog you have here.. It’s hard ways to have best
sex (http://www.fles.hlc.edu.tw) find high-quality writing
like yours nowadays. I truly appreciate people like you!
Take care!!
Hi this is somewhat of off topic but I was wondering if blogs
use WYSIWYG editors or if you have to manually code with HTML.
I’m starting a blog soon but have no coding expertise so I wanted
to get advice from someone with experience. Any help would be greatly appreciated!
Thank you, I have recently been looking for information about this subject for a while and yours is the
best I’ve came upon so far. But, what in regards to the bottom line?
Are you certain in regards to the source?
Appreciate it for this post, I am a big big fan of this site would like to continue updated.
my blog post … marijuana seeds [foro.mecanicasa.es]
This post will assist the internet users for
setting up new webpage or even a blog from start to
end.
It?s nearly impossible to find knowledgeable people for this subject, however, you sound like you
know what you?re talking about! Thanks
my blog post … skin health
Have you ever thought about writing an ebook or guest authoring on other blogs?
I have a blog based upon on the same ideas you discuss and would
love to have you share some stories/information. I know my visitors would enjoy your work.
If you are even remotely interested, feel free
to send me an e mail.
F*ckin’ remarkable issues here. I am very satisfied
to look your post. Thanks a lot and i’m looking forward to touch you.
Will you please drop me a mail?
My web page :: hemp seed oil uses
With havin so much written content do you ever run into any problems of
plagorism or copyright violation? My website has a lot of exclusive content I’ve either created myself
or outsourced but it appears a lot of it is popping it up all over the web without my permission. Do you know
any methods to help protect against content from being
ripped off? I’d really appreciate it.
I’m not sure where you are getting your information,
but good topic. I needs to spend some time learning much more or understanding more.
Thanks for great information I was looking for this information for
my mission.
Does your website have a contact page? I’m having problems locating it but,
I’d like to shoot you an e-mail. I’ve got some recommendations for your blog
you might be interested in hearing. Either way, great blog and I
look forward to seeing it develop over time.
Excellent blog here! Also your website loads up very fast!
What host are you using? Can I get your affiliate link to your host?
I wish my web site loaded up as fast as yours lol
I’m really impressed with your writing skills and also with the structure on your weblog.
Is this a paid theme or did you modify it your self? Either way stay up the excellent quality writing, it’s uncommon to see a nice weblog like this one these days..
I’m really enjoying the design and layout of your website.
It’s a very easy on the eyes which makes it much more enjoyable for me
to come here and visit more often. Did you hire out a developer to create your theme?
Superb work!
Hi there everyone, it’s my first pay a quick visit at this site, and article is
actually fruitful designed for me, keep up posting such posts.
Great blog you have here but I was curious if you knew
of any discussion boards that cover the same topics discussed
here? I’d really like to be a part of community where I can get
responses from other experienced people that share the
same interest. If you have any recommendations, please let me know.
Thank you!
I read this paragraph completely concerning the difference of latest and preceding technologies,
it’s awesome article.
This excellent website definitely has all the
info I wanted about this subject and didn’t know
who to ask.
I was just seeking this info for some time. After 6 hours of continuous Googleing, at last I got it in your web
site. I wonder what is the lack of Google strategy that don’t rank this kind of informative websites in top of the list.
Generally the top web sites are full of garbage.
Here is my web page; skin care p
Hmm is anyone else experiencing problems with the pictures on this blog loading?
I’m trying to figure out if its a problem on my
end or if it’s the blog. Any feedback would be greatly appreciated.
Awesome article.
Do you have a spam problem on this website; I also am a blogger,
and I was wanting to know your situation; we have developed some nice procedures and we are looking to trade strategies with others, be
sure to shoot me an e-mail if interested.
Excellent post. I was checking constantly this blog and I am
impressed! Extremely helpful information specially the last part 🙂 I care
for such information much. I was seeking this particular info
for a long time. Thank you and good luck.
Thanks for sharing your thoughts about website. Regards
hello there and thank you for your information – I’ve definitely picked
up anything new from right here. I did however expertise some technical points using
this site, as I experienced to reload the site lots of times
previous to I could get it to load properly. I had been wondering if your
hosting is OK? Not that I’m complaining, but slow loading instances
times will very frequently affect your placement in google
and can damage your quality score if advertising and marketing with Adwords.
Anyway I’m adding this RSS to my email and can look out for a lot more
of your respective intriguing content. Ensure that you update this again soon.
Hi, I think your site might be having browser compatibility issues.
When I look at your blog site in Opera, it looks fine but
when opening in Internet Explorer, it has some overlapping.
I just wanted to give you a quick heads up! Other then that, superb
blog!
Good way of describing, and pleasant article to obtain data about my
presentation topic, which i am going to present in academy.
Spot on with this write-up, I honestly think this web site needs a lot more attention.
I’ll probably be back again to read through more, thanks
for the info!
Highly descriptive article, I enjoyed that bit. Will there be a part 2?
If some one desires to be updated with newest technologies then he must be
visit this site and be up to date everyday.
Hello, after reading this amazing paragraph i am also happy to share
my experience here with colleagues.
Howdy! Do you know if they make any plugins to assist with SEO?
I’m trying to get my blog to rank for some targeted keywords but I’m not seeing very good gains.
If you know of any please share. Cheers!
Hi friends, how is the whole thing, and what
you wish for to say concerning this post, in my view
its in fact awesome for me.
Nice answer back in return of this difficulty with real arguments and
telling the whole thing regarding that.
Wow! At last I got a webpage from where I be capable of in fact get valuable data concerning
my study and knowledge.
Good post. I learn something totally new and challenging on blogs I stumbleupon every
day. It’s always exciting to read content from other writers and practice something
from other websites.
Your method of describing the whole thing in this paragraph is really nice, all be able to effortlessly be aware of it, Thanks a lot.
Major thanks for the blog article.Really thank you!
Say, you got a nice article.Really thank you! Fantastic.
Well I definitely liked reading it. This tip offered by you is very practical for proper planning.
Thanks for helping out and about, superb data. The a number of stages regarding man are generally infancy, childhood, adolescence, and obsolescence. by Bruce Barton.
Woman of Alien Great perform you have got done, this great site is admittedly great with great facts. Time is God as strategy for trying to keep anything from taking place directly.
You, my friend, ROCK! I found just the information I already searched all over the place and just could not locate it. What a perfect website.
Thanks a lot for sharing this with all of us you really know what you are talking about! Bookmarked. Kindly also visit my web site =). We could have a link exchange arrangement between us!
Amiodarone vs Procainamide for Ventricular Tachycardia – Resus
agtqvjjzgck
[url=http://www.gfg534n6122l4ie3e55j92cj1df5ron1s.org/]ugtqvjjzgck[/url]
gtqvjjzgck http://www.gfg534n6122l4ie3e55j92cj1df5ron1s.org/
スーパーコピーバッグ
Powerwall Battery
SMA35